Endocrine Abstracts

It has been previously shown that adrenal adenomas are associated with a variety of metabolic disturbances like glucose intolerance and obesity. The aim of this study is to demonstrate the risk of non-alcoholic fatty liver disease development in subjects with adrenal incidentalomas.Among 302 subjects referred between 2001 and 2008 for the evaluation of incidentally discovered adrenal mass, 150 subjects with appropriate data were included. Computed tomogr...

Adrenal adenomas are characterised with metabolic disturbances. The aim of this study is to demonstrate the changes in some metabolic and anthropometric parameters after 24 months follow up in subjects with non-functioning adrenal adenomas.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2 day 2 mg d...

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate carotid intima media thickness (IMT) as a robust indicator of atherosclerosis in subjects with AI.Of 49 subjects without findings of hypercortisolism or other adrenal gland disorders, 34 BMI-unmatched controls (C) and 18 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation including morning...

Increased use and improved technology of imaging procedures have led to increased recognition of adrenal incidentalomas. The aim of this study is to evaluate the natural course of benign adrenal tumours in terms of tumour growth and hormone secretion.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2...

Prediction of amputation would aid clinicians in the management of the diabetic foot infections. We aimed to assess the predictability of baseline and early post-treatment levels of acute phase reactants on the outcome of patients with diabetic foot infections.In this study, we included patients with infected diabetic foot ulcers who were hospitalized in Dokuz Eylul University Hospital between January 2003 and January 2008, of which data were collected p...

Although metformin crosses placenta, there is no current evidence whether the use of metformin in pregnancy is associated with increased risk of fetal and maternal complications. The aim of this present study is to investigate the attitudes of Turkish physicians in different specialties in terms of metformin use in pregnancy.Current opinions were assessed by interviewing physicians using a questionnaire. Nine hundred forty physicians were invited to join...

Women with a history of GDM may be at increased risk for future diabetes and cardiovascular disease. The aim of this study was to investigate the endothelium dependent hemostatic factors as well as the parameters of endothelial function and inflammation in women with pGDM.Eighty women with pGDM and 40 women (control) healthy women with normal glucose tolerance during pregnancy were studied. In all women, plasma glucose, insulin, C-peptid, lipid profile, ...

Introduction: Reduced creatinine clearance is related to an increased risk of diabetic foot ulcer development. Wound healing has been reported to be worse in diabetic patients with impaired kidney functions than general diabetic population. This study aimed to investigate the effect of creatinine clearance on the short term outcome of neuropathic diabetic foot ulcers.Materials and methods: Data from 147 neuropathic diabetic foot ulcer episodes were inclu...

Objectives: Endothelial dysfunction contributes to the development of atherosclerosis in diabetic subjects. Endothelin-1 (ET-1) is an endothelium derived vasoconstrictor. It has been shown that ET-1 levels are increased in a variety of situations such as diabetes, hypertension and obesity. Transforming growth factor beta1 (TGF-β1) is an important cytokine for the development of renal injury in type 2 diabetic patients and associated with hyperglycemia and insulin resistan...

Pregnancy is a prothrombotic condition with increased levels of several circulating coagulation factors. The aim of the present study is to investigate the effect of gestational diabetes on plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels.Plasma TAFI and PAI-1 antigen levels were measured in 26 pregnant women with gestational diabetes, 25 pregnant women with normal glucose tolerance, and age matched 24 non-pregnant women with no h...